Probiotics, Antibiotics and the Post-Antibiotic Microbiota

Starting soon · Not applicable · Has a placebo group

Conditions studied: Probiotic, Microbiome

In brief

Antibiotic therapy can cause gastrointestinal dysbiosis and this study will assess the impact of probiotic supplementation on microbiological composition and functionality pre- and post- antibiotic therapy

Key facts

Study ID

NCT07425704

Run by

Cultech Ltd

People needed

50

Starts

2026-04-13

Expected to finish

2026-12-01

Last updated by the study team

2026-03-18

Who can join

Age: 18 and older, up to 40. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults, aged 18-40.
• Been prescribed an oral dose of cephalosporin antibiotic lasting 5 - 10 days.
• Willing to provide stool samples and, for women, vaginal samples.
• Willing to avoid consumption of any other probiotic capsules/tablets during the study.

You may not qualify if…

• If antibiotics prescribed are intended to treat any gastrointestinal or vaginally related issue.
• Any antibiotic intake within the last 3 months.
• Immunodeficient or undergoing immunosuppressive therapy.
• Currently diagnosed with diabetes/cardiovascular disease/cancer/dementia.
• Any unexplained loss of weight in recent months.
• Known to be pregnant or <3 months postpartum.

Where it is running

• Comac Medical — Sofia, Bulgaria

Full record on ClinicalTrials.gov

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