Evaluation of a Stannous Fluoride Dentifrice for Control of Oral Malodor

Completed · Not applicable

Conditions studied: Oral Malodor (Halitosis)

In brief

This single-center, randomized, double-blind, two-treatment crossover clinical study evaluated the safety and efficacy of a stannous fluoride-containing dentifrice compared with a sodium fluoride control dentifrice for the control of intrinsic oral malodor. Adult subjects brushed twice daily with each product during separate treatment periods following standardized wash-out periods. Oral malodor was assessed using trained organoleptic judges applying a validated Odor Intensity (OI) scale at baseline and multiple post-treatment time points.

Key facts

Study ID

NCT07425509

Run by

Church & Dwight Company, Inc.

People needed

49

Starts

2024-09-09

Expected to finish

2024-11-04

Last updated by the study team

2026-02-23

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults ≥18 years of age in good general health
• Baseline odor intensity score ≥2 after approximately 12 hours of oral hygiene abstention
• Intra-oral source of oral malodor
• At least 18 natural teeth
• Willing to comply with oral hygiene, dietary, and behavioral restrictions
• Able to provide informed consent

You may not qualify if…

• Allergy to oral hygiene products
• Pregnant or nursing
• Serious medical conditions affecting oral malodor
• Recent antibiotic or anti-inflammatory medication use
• Smoker or user of smokeless tobacco
• Advanced periodontal disease, frank caries, or significant oral pathology
• Participation in another oral care study within 30 days

Where it is running

• Salus Research, Inc. — Fort Wayne, Indiana, United States

Full record on ClinicalTrials.gov

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