HELIOS Advanced: Human Oocyte Illumination to Enhance Development

Recruiting now · Not applicable

Conditions studied: IVF Outcomes

In brief

Oocytes need a lot of energy to complete meiosis and fertilize successfully. As women get older, the "power plants" of the cells (called mitochondria) don't work as well. This makes it harder for eggs and embryos to develop normally. One possible way to help is with a gentle light treatment called photobiomodulation (PBM). This uses a special type of red light that boosts energy production in cells and helps them stay healthy. This study will test whether adding this light treatment during in vitro fertilization (IVF) can improve embryo growth and pregnancy outcomes.

Key facts

Study ID

NCT07425080

Run by

Columbia University

People needed

270

Starts

2026-03-24

Expected to finish

2028-06-01

Last updated by the study team

2026-03-25

Who can join

Age: 18 and older, up to 48. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Female age between 18-48 years at the time of the IVF/ICSI cycle
• Undergoing blastocyst culture
• Using own oocytes
• Has at least two oocytes available for randomization
• Consenting to oocyte level randomization
• Plan to transfer euploid embryo within 6 months

You may not qualify if…

• Use of donor oocytes or gestational carrier
• Concurrent experimental laboratory inventions outside of protocol
• Refusal of randomization or request for non-standard handling

Where it is running

• Columbia University Fertility Center — New York, New York, United States (enrolling)

Full record on ClinicalTrials.gov

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