Hepatic Venous Pressure Gradient Versus Endoscopic Ultrasound-Guided Portal Pressure Gradient - Comparative Analysis (HEPCA)
Recruiting now · Not applicable
Conditions studied: Cirrhosis, Portal Hypertension, EUS, Non-Cirrhotic Portal Hypertension, HVPG, Hepatic Venous Pressure Gradient
In brief
The goal of this interventional trial is to compare in measuring of portal hypertension by HVPG and EUS-PPG in subject indicated to HVPG measurement. The primary question is whether EUS-PPG provides measurements really equivalent to HVPG in terms of gradient accuracy. Participants undergoing HVPG will first undergo the procedure while conscious, performed by the first operator. Immediately thereafter, HVPG will be repeated following the induction of anesthesia by a second operator blinded to the initial readings. Subsequently, EUS-PPG will be performed by an endoscopist, who will also be blinded to all previous pressure measurements.
Key facts
- Study ID
- NCT07424963
- Run by
- Military University Hospital, Prague
- People needed
- 40
- Starts
- 2025-05-30
- Expected to finish
- 2028-12-31
- Last updated by the study team
- 2026-02-20
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18-75 years at the time of enrollment; signed informed consent
- Clinical indication for HVPG measurement and/or transjugular liver biopsy for chronic advanced liver disease
You may not qualify if…
- Severe co-morbidities (e.g., advanced chronic heart failure, chronic renal insufficiency stage 4 and above, long-term poorly compensated diabetes mellitus with severe complications)
- Pregnancy
- Estimated patient non-compliance and/or not signing of the informed consent
- Documented iodine contrast dye allergy
- Presence of portal vein thrombosis or cavernomatous transformation of portal vein or hepatic vein obstruction
- Ascites Grade 3
- Biliary obstruction
- Anticoagulation or antiplatelet therapy, which cannot be discontinued
- INR > 1.5 and/or platelet count < 50,000/µl
- Hepatocellular carcinoma in the left lobe of the liver
- Surgically altered upper gastrointestinal tract anatomy
- State after transjugular intrahepatic portosystemic shunt
- State after liver transplantation
Where it is running
- Military University Hospital Prague — Prague, Bohemia, Czechia (enrolling)
- IKEM — Prague, Czechia (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.