Lactose Intolerance and Intestinal Permability

Enrolling by invitation

Conditions studied: Lactose Intolerance, Adult Type, Intestinal Permability, IBS (Irritable Bowel Syndrome)

In brief

"This study evaluates the interplay between lactose intolerance, intestinal barrier function (zonulin), and intestinal inflammation (fecal calprotectin) in adults, aiming to clarify their independent contributions to symptom severity and quality of life."

Key facts

Study ID

NCT07424898

Run by

Bezmialem Vakif University

People needed

200

Starts

2026-02-10

Expected to finish

2027-06-15

Last updated by the study team

2026-02-25

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18-70 years; experiencing chronic symptoms (diarrhea, bloating, abdominal pain, constipation, flatulence) for the past 3 months, potentially fitting IBS criteria.

You may not qualify if…

• Acute gastroenteritis (< 4 weeks), Active gastrointestinal bleeding (stomach, small intestine, and colon), Known celiac disease, Bariatric surgery or short bowel syndrome, Pregnancy or lactation, Type I and II Diabetes mellitus, Antibiotic use within the last 2 weeks, High-dose NSAIDs within the last 2 weeks, Initiation of probiotics or prebiotics within the last 4 weeks, High-dose PPI use (optional), Inflammatory bowel disease (IBD; ulceretive colitis and Crohn's colitis) with active severe flare (excluded from primary analyses, evaluated separately in subgroup analyses)

Where it is running

• Bezmialem Vakıf University Medical Faculty Hospital — Istanbul, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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