Chronic Pain After Combat-Related Traumatic Brain Injury (cTBI-Pain Study) A Prospective Cohort Study of Pain Chronification After Combat-Related Traumatic Brain Injury
Starting soon
Conditions studied: Pain, Chronic Pain, Chronic Pain Due to Injury
In brief
Combat-related traumatic brain injury (cTBI), particularly blast-related injury, is frequently associated with the development of persistent and disabling chronic pain. This prospective observational cohort study aims to determine the incidence, phenotypes, and early predictors of chronic pain following mild to moderate combat-related TBI. Adults will be enrolled within 14 days of injury and followed for 6 months. The primary endpoint is clinically significant chronic pain at 3 months, defined by pain intensity and functional interference. The study will evaluate clinical, psychological, and physiological factors to develop and internally validate a prognostic model for chronic pain risk after cTBI.
Key facts
- Study ID
- NCT07424248
- Run by
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
- People needed
- 100
- Starts
- 2026-02-15
- Expected to finish
- 2026-12-15
- Last updated by the study team
- 2026-02-24
Who can join
Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age 18 to 60 years
- Combat-related traumatic brain injury (blast, impact, or combined mechanism)
- Mild to moderate traumatic brain injury
- Enrollment within 14 days after injury
- Ability to provide written informed consent
You may not qualify if…
- Severe traumatic brain injury with prolonged impaired consciousness
- Pre-existing severe psychiatric disorder unrelated to trauma
- Chronic pain condition predating the traumatic brain injury
- Inability to complete follow-up assessments
- Severe medical condition limiting participation
Where it is running
- Superhumans War Trauma Center — Lviv, Ukraine
Full record on ClinicalTrials.gov
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