The Effect of Exercise-Induced Irisin on Brain Function and Postoperative Delirium in Older Adults

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Conditions studied: Post Operative Delirium

In brief

The goal of this observational study is to learn how exercise-induced irisin protects the brain. It also explores irisin's effect on postoperative delirium (POD) in older adults. The main questions it aims to answer are: Does daily activity link to POD? Does irisin play a mediating role in this process? Researchers will enroll active and inactive adults aged 65 and older. All will have surgery under spinal anesthesia. The researchers will measure irisin levels in spinal fluid. They will track POD and other complications for five days after surgery.

Key facts

Study ID: NCT07424170
Run by: Peking University People's Hospital
People needed: 140
Starts: 2026-03-15
Expected to finish: 2026-12-31
Last updated by the study team: 2026-03-10

Who can join

Age: 65 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Aged ≥ 65 years;
Classified as ASA physical status I to III;
Scheduled for non-cardiovascular surgery under spinal anesthesia or combined spinal-epidural anesthesia;
Expected surgical duration of at least 2 hours;
Voluntarily provide written informed consent and agree to participate in this study.

You may not qualify if…

Significant change in exercise status within the past 7 days due to injury or other reasons;
Contraindications to neuraxial anesthesia;
Unable to assess cognitive function or Montreal Cognitive Assessment (MoCA) score < 23;
Preoperative diagnosis of delirium;
History of traumatic brain injury or neurosurgery;
Long-term opioid use or history of alcohol abuse;
Planned surgery cancelled or changed (including intraoperative events that significantly alter the procedure or duration);
Change in anesthesia method.

Full record on ClinicalTrials.gov

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