Multimodal Neuromonitoring During Normothermic Regional Perfusion for Organ Donors Determined Dead by circuLatory Criteria Following Withdrawal of Life Sustaining Measures
Recruiting now
Conditions studied: Organ Preservation, Brain Reperfusion or Regain of Brain Function During Normothermic Regional Perfusion
In brief
The aim of this study is to demonstrate that cerebral blood flow and brain function do not resume after death declaration in organ donors who undergo normothermic regional perfusion to restore organ function following death determination by circulatory criteria, when appropriate safeguards are applied. To assess the absence of cerebral perfusion and function, investigators will use continuous and comprehensive multimodal neuromonitoring throughout the withdrawal of life-sustaining therapies, the dying process and the NRP procedure.
Key facts
- Study ID
- NCT07423936
- Run by
- University of British Columbia
- People needed
- 30
- Starts
- 2025-02-24
- Expected to finish
- 2028-12-01
- Last updated by the study team
- 2026-02-20
Who can join
Age: 19 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Age > 18;
- Planned DCD within the next 96 hours.
You may not qualify if…
- Coagulopathy (International normalized ratio > 1.5, prothrombin time > 45 seconds, platelets < 50);
- Therapeutic anticoagulant medication administration.
Where it is running
- Vancouver General Hospital — Vancouver, British Columbia, Canada (enrolling)
Full record on ClinicalTrials.gov
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