PlaCEUS: Feasibility Study of Contrast-enhanced Ultrasound to Visualize Maternal Uterine Spiral Arteries Postpartum.

Recruiting now · Not applicable

Conditions studied: Spiral Arteries, Uterine Artery Hemodynamics, Contrast Enhanced Ultrasound, Doppler Parameters, Resistance Index, Pulsatility Index, Systolic/Diastolic Ratio

In brief

During pregnancy, unique blood vessels form within the uterine wall, known as spiral arteries. These vessels originate from the uterine artery, which is the main artery supplying blood to the uterus. Throughout pregnancy, spiral arteries undergo significant changes to increase blood and oxygen flow to the placenta, ensuring the developing baby receives adequate nutrients. When these arteries fail to remodel properly, complications such as pre-eclampsia or fetal growth restriction can occur. Until now, direct observation and evaluation of spiral arteries during pregnancy has not been feasible. Contrast-enhanced ultrasound may provide a breakthrough in this area. In this study, the investigators aim to use this imaging technique to visualize spiral arteries after the placenta has been delivered. If successful, this could allow to assess their structural quality. Additionally, the investigators will employ ultrasound to monitor physiological changes in the uterine artery during late pregnancy (after 37 weeks), during labour, and postpartum. By conducting these measurements, the investigators hope to develop methods for detecting spiral artery abnormalities earlier in pregnancy. Early identification could enable timely interventions and help prevent severe complications.

Key facts

Study ID

NCT07422181

Run by

Maxima Medical Center

People needed

5

Starts

2025-12-17

Expected to finish

2026-07-01

Last updated by the study team

2026-02-19

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Pregnant patient at a minimum age of 18 years
• Singleton pregnancy at term (≥37 weeks gestation)
• Planning to deliver at the Máxima Medical Centre
• Able to provide informed consent
• Intravenous access present at the time of delivery

You may not qualify if…

• Multiple gestation pregnancy
• Contra-indications to CEUS, e.g. known allergy for constituents of SonoVue™
• Planning on breastfeeding
• Medical emergency during or after delivery, which makes CEUS impossible or undesirable
• No intravenous access present at the time of delivery
• Body Mass Index >40 kg/m2.
• Pre-eclampsia requiring medication
• Foetal growth restriction < p3

Where it is running

• Máxima Medical center — Veldhoven, Netherlands (enrolling)

Full record on ClinicalTrials.gov

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