Multidisciplinary Analysis by Morphological and Mechanical Evaluation of the Aortic Wall in Patients Undergoing Cardiac Surgery.
Recruiting now
Conditions studied: Aortic Aneurysm, Aortic Aneurysm and Dissection
In brief
Surgical indication in patients suffering from Ascending aorta aneurysm is currently based mainly on the maximum diameter of the aortic dilatation and on the yearly growth rate. Several clinical preoperative patients characteristics have been, potentially, correlated to impaired mechanical characteristics of aortic wall, and therefore to an increased risk of rupture and or dissection. On other hands, such suppositions have been never confirmed, as a full characterization of the mechanical behaviour of the ascending aortic tissue, especially in case of aneurysm, has not been fully clarified yet. Objective of this observational study is to better elucidate, using direct in vivo evaluation, the mechanical characteristics of the aortic wall in patients with ascending aorta diseases. Our study will have a further peculiar characteristic as we have the intention of compare such mechanical characteristics to those of patients, without known aortic diseases, undergoing heart transplantation. Potential correlation between, directly measured mechanical characteristics of the aortic wall, and preoperative parameters (anagraphic patients characteristics, clinical data and diagnostic tests) will be also investigated.
Key facts
- Study ID
- NCT07422129
- Run by
- Fondazione IRCCS Policlinico San Matteo di Pavia
- People needed
- 250
- Starts
- 2015-03-24
- Expected to finish
- 2027-12-31
- Last updated by the study team
- 2026-02-19
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Patients undergoing surgery including ascending aorta replacement at our Department and/or heart transplantation
You may not qualify if…
- Patients with biological hazard (HBC/HIV +)
Where it is running
- Fondazione IRCCS Policlinico San Matteo di Pavia — Pavia, Lombardy, Italy (enrolling)
Full record on ClinicalTrials.gov
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