Erythrodiol in Pomace Olive Oil as a Protective Agent Against Atherosclerosis
Starting soon · Phase 2
Conditions studied: Atherosclerosis Cardiovascular Disease
In brief
The goal of this postprandial clinical trial is to learn whether erythrodiol, a triterpene naturally present in pomace olive oil, can modulate the cell foam formation, ine of the first steps in atherosclerosis. The main questions it aims to answer are: Is erythrodiol bioavailable in humans when administered as pomace olive oil? Does acute erythrodiol intake reduce postprandial triglyceride excursions after a high-fat meal? Does erythrodiol reduce the intake of postprandial triglyceride-rich lipoproteins by macrophages? Researchers will compare participants receiving test meals enriched with different concentrations of erythrodiol (low, medium, high) to see if the intervention leads to improved postprandial metabolic and vascular responses. Participants will: Attend the research facility after an overnight fast. Consume a high-fat test meal enriched with a different doses of erythrodiol Undergo serial postprandial assessments over several hours, including: Blood sampling for lipids, glucose, inflammatory markers, and oxidative stress biomarkers Monitoring of subjective tolerability and adverse events
Key facts
- Study ID
- NCT07422051
- Run by
- Spanish National Research Council
- People needed
- 22
- Starts
- 2026-02-21
- Expected to finish
- 2026-12-30
- Last updated by the study team
- 2026-02-19
Who can join
Age: 18 and older, up to 40. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Adults aged 18 to 40 years.
- Male or female volunteers.
- Healthy individuals with no diagnosed diseases.
- Normal-weight participants with a Body Mass Index (BMI) between 18.5 and 24.9 kg/m².
- Ability to provide voluntary informed consent.
- Willingness to comply with all study procedures.
- Availability to participate in the two-phase selection process, including initial screening and subsequent laboratory tests.
You may not qualify if…
- Presence of any type of disease, including digestive, metabolic, endocrine, infectious, neoplastic conditions, or associated allergies and food intolerances.
- Current use of any medication, except hormonal contraceptives.
- Pregnant or breastfeeding women.
- Participation in a clinical trial with an investigational product within the last 60 days, or current enrolment in a clinical trial.
- Any physical or intellectual limitation that, in the opinion of the investigator, could impede following or completing the study protocol.
Where it is running
- Instituto de la Grasa-CSIC — Seville, Spain
Full record on ClinicalTrials.gov
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