A Study Evaluating the Performance of Using AI Software and Chest X-rays to Screen for Osteoporosis as Compared to Standard DXA Scans in Patients 50 Years and Older

Recruiting now

Conditions studied: Osteoporosis, Osteopenia

In brief

The goal of this study is to assess the performance of an artificial intelligence software (Osteo Signal) in detecting osteoporosis risk in adults 50 years and older. The main question it aims to answer is: What is the accuracy of the software in detecting osteoporosis risk on chest x-ray images as compared to the standard technique of dual-energy x-ray absorptiometry (DXA)? There is no direct involvement of participants in this study as it will use data from individuals who have already had a chest x-ray and a DXA scan taken in the past.

Key facts

Study ID

NCT07421713

Run by

Promedius Inc

People needed

595

Starts

2026-02-10

Expected to finish

2026-03-01

Last updated by the study team

2026-02-19

Who can join

Age: 50 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age ≥50 years at the time of chest X-ray
• Availability of
• Posteroanterior (PA) Chest X-ray and
• DXA scan with a valid T-score measurement where both the DXA scan and Chest x-ray examinations were performed within 6 months (182 days) of each other and
• Available X-ray and DXA scans performed on or after 01-Jan-2010.
• Complete metadata (sex and age) available on PACS or hospital records.

You may not qualify if…

• Non-diagnostic Quality or Incomplete Imaging of:
• DXA scan inadequacy: Missing T-score from a technically inadequate scan.
• PA Chest X-ray technical inadequacy: Non-PA projection, significant motion artefacts, inadequate visualisation of thoracic structures, or missing DICOM metadata.
• Image format incompatibility: Non-DICOM format or corrupted image files that would prevent AI analysis
• PA Chest X-ray > ±6 months from the date of the DXA scan.
• Previous diagnosis or treatment of Osteoporosis prior to the DXA scan used in the Study.
• diagnosis of osteoporosis (T-score ≤-2.5), or current/recent anti- osteoporotic medications, within 12 months prior to the DXA scan used in the study.
• Current or recent anti-osteoporotic medications for 3 months (91 days) continuously prior to the Chest x-ray used in the Study.
• Diagnosis of any metabolic bone disease prior to the DXA scan used in the study.
• Diagnosis of metabolic bone disease other than Osteoporosis or Osteopenia, up to a maximum of 3 months (91 days) after the DXA scan.
• Major Chest Wall or Spinal Deformities, including but not limited to:
• Severe structural deformities: Thoracic scoliosis with Cobb angle >40°, severe kyphosis, or chest wall deformities (pectus excavatum/carinatum) affecting >30% of the thoracic cage.
• Surgical hardware: Previous thoracic/spinal surgery with metallic implants obscuring anatomical landmarks required for AI analysis.
• Pathological conditions: Extensive pulmonary consolidation, pleural effusion, lesions or masses obscuring >30% of thoracic skeletal structures
• Subject has opted out of confidential data being used for research purposes

Where it is running

• Barts Health NHS Trust — London, United Kingdom (enrolling)
• Erasmus University Medical Center Rotterdam, — Rotterdam, Netherlands
• Mid and South Essex NHS Foundation Trust — Westcliff-on-Sea, Essex, United Kingdom

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.