Adding Amantadine or Duloxetine to Pregabalin on Occurrence of Post Mastectomy Pain Syndrome

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Amantadine, Duloxetine, Pregabalin, Mastectomy, Pain Syndrome

In brief

This study aims to evaluate the additive effect of Amantadine or Duloxetine to Pregabalin on development of post mastectomy pain syndrome

Key facts

Study ID

NCT07421427

Run by

Cairo University

People needed

150

Starts

2026-02-21

Expected to finish

2027-01-01

Last updated by the study team

2026-02-24

Who can join

Age: 18 and older, up to 65. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Age from 18 to 65 years.
• American society of anesthesiologists (ASA) Physical status II, III.
• Body mass index (BMI): (20-40) kg/m2.
• Type of surgery: patients undergoing modified radical mastectomy for breast cancer.

You may not qualify if…

• Patient refusal.
• Patients with Known sensitivity or contraindication to drug used in the study.
• History of psychological disorders and/or chronic pain and drug abuse patients.
• Previous administration of antidepressants, anticonvulsants, or opioids before surgery.
• Severe respiratory or cardiac disorders.
• Advanced liver or kidney disease.
• Previous breast surgery

Where it is running

• Cairo University — Cairo, Egypt (enrolling)

Full record on ClinicalTrials.gov

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