DETERMINATION OF THE EFFECTS OF STAINLESS STEEL CROWNS CEMENTED WITH RESIN CEMENTS ON INTERLEUKIN-10, 12, 18 LEVELS IN GINGIVAL CREVICULAR FLUID

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Conditions studied: Dental Caries, Gingival Inflammation, Periodontal Response to Dental Restorative Materials

In brief

This split-mouth clinical study aimed to evaluate the early effects of stainless steel crowns cemented with self-adhesive resin cement and high-viscosity glass ionomer cement on clinical periodontal parameters and interleukin-10 (IL-10), interleukin-12 (IL-12), and interleukin-18 (IL-18) levels in gingival crevicular fluid in pediatric patients. The study included 45 systemically healthy children aged 6-10 years. Stainless steel crowns were placed on the mandibular second primary molars (teeth 75 and 85) in each patient; tooth 75 was cemented with a self-adhesive resin cement (G-Cem ONE™, GC, Japan), while tooth 85 was cemented using a high-viscosity glass ionomer restorative material (EQUIA Forte™ HT, GC, Tokyo, Japan). Plaque index, gingival index, and bleeding on probing were recorded before treatment and one week after cementation. Gingival crevicular fluid samples were collected at the same time points, and IL-10, IL-12, and IL-18 levels were analyzed using the ELISA method. A statistically significant reduction in plaque index values was observed in both cement groups at the one-week follow-up (p\<0.001), whereas no significant differences were found in gingival index or bleeding on probing values (p\>0.05). IL-10 and IL-12 levels did not change significantly in either group, whereas IL-18 levels decreased significantly in the resin cement group and were significantly higher in the glass ionomer cement group postoperatively. These findings suggest that although different cementation materials used for stainless steel crowns yield similar short-term clinical periodontal outcomes, material-related differences may exist in gingival biological responses, particularly with respect to IL-18 levels.

Key facts

Study ID

NCT07421206

Run by

Afyonkarahisar Health Sciences University

People needed

45

Starts

2026-02-16

Expected to finish

2026-05-30

Last updated by the study team

2026-02-19

Who can join

Age: 6 and older, up to 10. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Children aged 6-10 years
• Systemically healthy pediatric patients
• Presence of bilateral mandibular second primary molars (teeth 75 and 85) requiring stainless steel crown restoration
• Absence of clinical signs of active periodontal disease
• Cooperative behavior sufficient to allow dental treatment and gingival crevicular fluid sampling
• Written informed consent obtained from parents or legal guardians

You may not qualify if…

• Presence of systemic diseases or medical conditions affecting periodontal health or immune response
• Use of antibiotics, anti-inflammatory drugs, or immunosuppressive medications within the last month
• Poor oral hygiene or untreated periodontal disease
• Teeth with pulpal pathology, mobility, or advanced root resorption
• History of allergy to dental materials used in the study
• Lack of parental consent or inability to complete follow-up examination

Where it is running

• Afyonkarahisar Health Science University — Afyonkarahisar, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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