Mechanical Insufflation-Exsufflation in Critically Ill Patients

Recruiting now

Conditions studied: Airway Clearance, Mechanical Insufflation-exsufflation, Mechanical Insufflation-exsufflation Session ( With Cough Assist), Delphi Study, Consensus, Critical Illness, Critical Care, Critical Care, Intensive Care

In brief

Mechanical insufflation-exsufflation (MI-E) is an established airway clearance technique for patients with chronic conditions like neuromuscular diseases. However, its use in critically ill ICU patients remains inconsistent and lacks standardized guidelines. Despite growing research, current practices vary widely in patient selection, treatment protocols, and safety management, with limited high-quality evidence to support clear recommendations. To address this gap, an international, multidisciplinary Delphi consensus study is needed to establish expert-based best practices and feasible guidelines for the safe and effective implementation of MI-E in the intensive care setting.

Key facts

Study ID

NCT07420946

Run by

Medipol University

People needed

30

Starts

2026-06-10

Expected to finish

2026-12-01

Last updated by the study team

2026-06-17

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Healthcare professionals with documented clinical experience in critical care medicine, pulmonology, anesthesiology, respiratory therapy, or physiotherapy with involvement in airway clearance strategies.
• Demonstrated experience or recognized expertise in the clinical use of MI-E, either in critically ill patients or in patients with complex respiratory conditions.
• A minimum of 5 years of clinical experience in their respective field, or a proven academic or clinical contribution related to MI-E.
• Willingness to participate in multiple Delphi rounds and to provide informed consent.
• Ability to complete the questionnaires in English.

You may not qualify if…

• Lack of direct clinical or academic experience related to MI-E or airway clearance techniques.
• Inability or unwillingness to provide informed consent.
• Failure to complete the first Delphi round after formal invitation and consent.
• Withdrawal of consent at any stage of the Delphi process.

Where it is running

• Monaldi Hospital A.O.R.N. dei Colli — Naples, Italy (enrolling)
• University of Naples Federico II — Naples, Italy (enrolling)
• Hospital General Universitario Morales Meseguer — Murcia, Spain (enrolling)
• İstanbul Medipol University — Istanbul, Istanbul, Turkey (Türkiye) (enrolling)

Full record on ClinicalTrials.gov

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