A Study Of Auricular Transcutaneous Vagus Nerve Stimulation In Chronic Dizziness

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Chronic Dizziness, Persistent Postural Perceptual Dizziness

In brief

The purpose of this study is to measure the change in dizziness, as measured by change in Dizziness Handicap Inventory (DHI) score, following a 4-week treatment period with auricular transcutaneous vagus nerve stimulation (aTVNS).

Key facts

Study ID

NCT07420803

Run by

Mayo Clinic

People needed

60

Starts

2026-03-23

Expected to finish

2027-03-01

Last updated by the study team

2026-04-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 18-75, Persistent Postural-Perceptual Dizziness (PPPD) diagnosis per International Classification of Vestibular Disorders (ICVD).
• Persistent dizziness ≥3 months and at least 1 dizziness exacerbation/day during 2-week run-in.
• On stable medications/therapy for ≥4 weeks prior to baseline (if any).

You may not qualify if…

• Uncompensated peripheral/central vestibular deficit, sensory-afferent or cerebellar ataxia.
• Cardiac disease (coronary disease, unstable arrhythmia), recurrent syncope (>1 in past 12 months).
• Neck surgery, vagotomy, or any condition interfering with vagal stimulation.
• Pregnancy.

Where it is running

• Mayo Clinic in Florida — Jacksonville, Florida, United States (enrolling)

Full record on ClinicalTrials.gov

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