Respiratory and Real-time Dynamics in Exercise-Induced Paradoxical Vocal Fold Motion
Recruiting now · Early Phase 1
Conditions studied: Exercise-Induced Vocal Cord Dysfunction, Paradoxical Vocal Fold Motion, Vocal Cord Dysfunction
In brief
The overall objectives of the proposed research are to: 1. Evaluate the diagnostic validity of a novel mechano-acoustic signatures of task-characteristic activity during symptomatic and asymptomatic breathing in Exercise-Induced Laryngeal Obstruction (EILO) patients with the use of a novel miniature, soft wearable skin-mounted device, 2. Identify the mechanism/s of paradoxical respiratory control in EILO by quantifying the relationship between pulmonary mechanics, partial pressure of carbon dioxide (PCO2) maintenance, and vocal fold aperture prior to and during symptomatic and asymptomatic exercise ventilation, and 3. Identify unique biophysiological factors contributing to EILO among exercisers with and without EILO. Findings will be highly novel and clinically significant for early identification and management of EILO. For the study there are three separate visits: 1. Free running with the device on the neck 2. Exercise treadmill study 3. Undergoing MRI (Magnetic Resonance Imaging) of the vocal tract.
Key facts
- Study ID
- NCT07420530
- Run by
- Indiana University
- People needed
- 120
- Starts
- 2026-04-20
- Expected to finish
- 2032-01-20
- Last updated by the study team
- 2026-03-02
Who can join
Age: 18 and older, up to 26. Sex: any. Healthy volunteers: accepted.
Where it is running
- Indiana University — Bloomington, Indiana, United States (enrolling)
Full record on ClinicalTrials.gov
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