A New Diagnostic Algorithm to Non-invasively Track Fibrotic Changes in Myeloproliferative Neoplasms Based on C-C Chemokine Receptor 2 Detection. From Flow Cytometry to the Development of Targeted Positron Emission Tomography Molecular Imaging. Pre-clinical Studies and First In-human Proof of Concept

Recruiting now · Not applicable

Conditions studied: Myelofibrosis (MF)

In brief

Chronic "Philadelphia-negative" myeloproliferative syndromes are chronic blood disorders. They include essential thrombocythemia, polycythemia vera, and myelofibrosis. Myelofibrosis may arise de novo ("primary myelofibrosis") or represent the evolution of essential thrombocythemia or polycythemia vera ("secondary myelofibrosis"). The myelofibrotic stage-characterized, as the name implies, by the presence of bone marrow fibrosis (deposition of scar-like tissue)-is generally associated with a more severe and symptomatic disease. To date, the only way to assess fibrotic progression in these disorders is bone marrow biopsy. The aim of this project is to evaluate whether the identification, tracking, and quantification of cells expressing a specific receptor (CCR2), a selective biomarker of fibrosis, may allow early and non-invasive identification of the fibrotic stage of the disease through: * laboratory analysis on a blood sample (using flow cytometry) * use in PET-CT (positron emission tomography combined with computed tomography) of a tracer specific for the CCR2 receptor, capable of selectively binding to CCR2-expressing cells (⁶⁸Ga-DOTA-ECL1i).

Key facts

Study ID

NCT07419178

Run by

Azienda Ospedaliero-Universitaria di Parma

People needed

265

Starts

2023-09-05

Expected to finish

2027-04-30

Last updated by the study team

2026-02-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of ET/PV/prePMF/overtPMF according to the WHO 2016 criteria and of SMF according to the IWG-MRT criteria (with histopathological data).
• Age >= 18 yrs
• ECOG performance status <=3

You may not qualify if…

• Pregnancy/breastfeeding
• Ongoing therapy with immunomodulatory drugs (JAK-inhibitors, interferon).
• For PET imaging, patients should be off any cytoreductive treatment for at least 3 months.
• Antiplatelet agents are allowed

Where it is running

• Dipartimento di Medicina e Chirurgia — Parma, Italy, Italy (enrolling)

Full record on ClinicalTrials.gov

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