Early Co-Administration of Crystalloid Fluid and Norepinephrine for Preventing Acute Kidney Injury in Septic Shock
Starting soon · Not applicable
Conditions studied: Septic Shock, Acute Kidney Injury
In brief
Septic shock is a life-threatening condition that can cause severe circulatory failure and damage to vital organs, including the kidneys. One of the most serious complications of septic shock is acute kidney injury (AKI), which is associated with increased morbidity and mortality. This study aims to evaluate the effect of early co-administration of crystalloid fluid resuscitation (30 mL/kg body weight) and norepinephrine on preventing acute kidney injury and improving hemodynamic stability in adult patients with septic shock. Patients will receive standard initial fluid resuscitation combined with early norepinephrine infusion according to a predefined clinical protocol. Changes in blood pressure, urine output, and other hemodynamic parameters will be observed before and after the intervention. The findings of this study are expected to provide evidence to support early hemodynamic optimization strategies for reducing the risk of acute kidney injury in septic shock patients.
Key facts
- Study ID
- NCT07418541
- Run by
- Universitas Sumatera Utara
- People needed
- 100
- Starts
- 2026-04-23
- Expected to finish
- 2026-12-01
- Last updated by the study team
- 2026-02-18
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Adult patients aged 18 years or older.
- Diagnosed with septic shock based on clinical criteria.
- Require fluid resuscitation and vasopressor support.
- Admitted to the intensive care unit or emergency department.
- Have complete baseline clinical and hemodynamic data.
You may not qualify if…
- Patients with end-stage renal disease or receiving chronic dialysis.
- Known pregnancy.
- History of severe chronic kidney disease.
- Patients with limitations of care or do-not-resuscitate orders.
- Incomplete clinical data for outcome assessment.
Full record on ClinicalTrials.gov
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