"Effect of Albumin Combined With Furosemide in Critically Ill Patients With Fluid Overload: Impact on Urine Output and Renal Function"

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Urine Output Decreased

In brief

This study aims to compare the effectiveness of furosemide alone versus the combination of furosemide plus albumin in critically ill adult patients with fluid overload. The trial evaluates whether co-administration of albumin enhances diuretic response compared with standard furosemide therapy. The primary outcomes include urine output at 2 hours, changes in renal perfusion markers, and biochemical parameters. Secondary outcomes include changes in mean arterial pressure, electrolyte balance, and renal resistance index. The study seeks to determine whether adding albumin provides a clinically meaningful improvement in diuresis and renal function compared with furosemide monotherapy.

Key facts

Study ID

NCT07417969

Run by

Jose J Zaragoza, MD MSc

People needed

56

Starts

2025-06-01

Expected to finish

2026-10-31

Last updated by the study team

2026-06-16

Who can join

Age: 18 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults ≥18 years
• Critically ill patients admitted to the intensive care unit (ICU)
• Presence of oliguria defined as urine output <0.5 mL/kg/hour for at least 6 hours

You may not qualify if…

• Refusal to participate by the patient or legal representative
• Patients receiving palliative or end-of-life care
• Acute or chronic kidney failure requiring ongoing renal replacement therapy at enrollment
• Chronic dialysis dependency
• Participation in another interventional clinical trial
• Pregnant or lactating women

Where it is running

• 76000 — Querétaro City, Querétaro, Mexico (enrolling)

Full record on ClinicalTrials.gov

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