Ketogenic Diet to Reduce Osteoarthritis Pain in MCI

Starting soon · Not applicable

Conditions studied: Osteoarthritis (OA) of the Hip, Osteoarthritis (OA) of the Knee, Osteoarthritis (OA) of the Shoulder, Osteoarthritis, Mild Cognitive Impairment, MCI, Mild Cognitive Impairment (MCI), Dementia

In brief

Osteoarthritis and mild cognitive impairment are common conditions that share underlying biological processes related to metabolism and inflammation. This study will examine whether a well-formulated ketogenic diet influences pain, physical function, and cognitive outcomes in adults with osteoarthritis and mild cognitive impairment. Participants will follow a supervised ketogenic dietary intervention, with assessments conducted before and after the intervention to evaluate changes in symptoms and related biological markers. The goal of this study is to better understand shared mechanisms between joint pain and cognitive health and to explore whether a ketogenic dietary approach may support symptom management in these populations.

Key facts

Study ID

NCT07417891

Run by

University of Kansas Medical Center

People needed

10

Starts

2026-06-01

Expected to finish

2027-06-01

Last updated by the study team

2026-05-04

Who can join

Age: 55 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• English speaking
• Diagnosis of major joint osteoarthritis
• Diagnosis of mild cognitive impairment

You may not qualify if…

• Diabetes that requires insulin
• Cancer requiring chemo- or radiation therapy in the last 2 years
• Cardiac event within 1 year
• Recent history of renal stones
• Diagnosis of fibromyalgia
• Already following a ketogenic diet
• Following a dietary pattern that does not allow for a ketogenic approach
• Unable to control one's diet

Where it is running

• University of Kansas Medical Center — Fairway, Kansas, United States

Full record on ClinicalTrials.gov

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