Continued Pressure for Alveolar Protection (CPAP Trial)

Recruiting now · Not applicable

Conditions studied: Bronchopulmonary Dysplasia (BPD)

In brief

The objective of the CPAP Trial is to test whether extending CPAP until 34 weeks' PMA or for at least 2 additional weeks compared to weaning to a nasal canula will decrease the likelihood of bronchopulmonary dysplasia or death at 36 weeks' PMA.

Key facts

Study ID

NCT07417111

Run by

NICHD Neonatal Research Network

People needed

860

Starts

2026-11-05

Expected to finish

2029-01-30

Last updated by the study team

2026-07-14

Who can join

Age: any, up to 1. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Gestational age <29 weeks at birth
• PMA <32 weeks at study entry
• On treatment with CPAP without a rate in FiO2 <0.25 and PEEP of 4-5 cmH2O
• Meet stability criteria:
• If previously intubated must be extubated ≥ 72 hours
• <3 self-resolving apneas (≤ 20 s) and/or bradycardia (<100 bpm) in any hour over previous 6 hours
• No episodes of apnea or bradycardia requiring intervention (oxygen/stimulation/bag and mask) for 24 hours
• Parents/legal guardians consent for enrollment

You may not qualify if…

• Major malformation
• Neuromuscular condition that affects respiration
• Terminal illness
• Decision to withhold or limit support
• Too sick to participate in opinion of Attending physician
• Clinical shock, sepsis
• Planned surgery during study period

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States (enrolling)
• Stanford University — Palo Alto, California, United States (enrolling)
• Sharp Mary Birch Hospital for Women & Newborns — San Diego, California, United States (enrolling)
• Emory University — Atlanta, Georgia, United States (enrolling)
• Northwestern Lurie Children's Hospital of Chicago — Chicago, Illinois, United States (enrolling)
• University of Iowa — Iowa City, Iowa, United States (enrolling)
• University of Mississippi Medical Center - Children's of Mississippi — Jackson, Mississippi, United States (enrolling)
• University of New Mexico — Albuquerque, New Mexico, United States (enrolling)
• Duke University — Durham, North Carolina, United States (enrolling)
• Cincinnati Children's Medical Center — Cincinnati, Ohio, United States (enrolling)
• Case Western Reserve University, Rainbow Babies and Children's Hospital — Cleveland, Ohio, United States (enrolling)
• University of Pennsylvania — Philadelphia, Pennsylvania, United States (enrolling)
• University of Texas Southwestern Medical Center at Dallas — Dallas, Texas, United States (enrolling)
• University of Texas Health Science Center at Houston — Houston, Texas, United States (enrolling)
• University of Utah — Salt Lake City, Utah, United States (enrolling)

Full record on ClinicalTrials.gov

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