Analysis of the Composition of the Intestinal Microbiota in Patients Post-intestinal Anastomosis

Recruiting now

Conditions studied: Abdominal Surgery

In brief

Recent research suggests a significant link between gut microbiota and anastomotic leakage (AL) in colorectal surgery. Patients who develop AL have a higher abundance of bacteria from the Lachnospiraceae family and lower microbial diversity. Considering the bibliographic data, our main interest is to analyze the microbial population of patients in our social environment and then look for differences in the microbiome between those who have suffered an anastomotic dehiscence (around 8-9% according to the results of our hospital's Surgery Department) and those who have not.

Key facts

Study ID

NCT07416760

Run by

Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz

People needed

30

Starts

2026-02-14

Expected to finish

2026-12-14

Last updated by the study team

2026-02-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients who have undergone colorectal intestinal anastomosis.
• Signing of the informed consent form.
• Age ≥18 years with good functional status.
• Availability for postoperative follow-up.

You may not qualify if…

• Emergency surgery.
• Intra-abdominal sepsis or previous dehiscence.
• Severe immunosuppression.
• Use of antibiotics in the 3 months prior to preoperative preparation.
• Pregnancy or breastfeeding.

Where it is running

• University Hospital Fundación Jiménez Díaz — Madrid, Spain (enrolling)

Full record on ClinicalTrials.gov

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