A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 Diabetes
Recruiting now · Phase 2 · Has a placebo group
Conditions studied: Diabetes Mellitus, Type 2
In brief
This study is being done to look at the effect and safety of different doses of NNC0662-0419 in people living with type 2 diabetes when compared to placebo or semaglutide. The purpose of this clinical study is to find out if NNC0662-0419 is effective and safe for treating people living with type 2 diabetes. Participants will get either NNC0662-0419, semaglutide or placebo. Which treatment participants get is decided by chance. NNC0662-0419 is a new medicine which cannot be prescribed by doctors but has previously been tested in humans. Semaglutide is an approved medication to treat type 2 diabetes.
Key facts
- Study ID
- NCT07415954
- Run by
- Novo Nordisk A/S
- People needed
- 270
- Starts
- 2026-04-17
- Expected to finish
- 2027-10-01
- Last updated by the study team
- 2026-06-30
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male or female (sex at birth).
- Age 18-75 years (both inclusive) at the time of signing the informed consent.
- Glycated haemoglobin (HbA1c) of 7.0-10.0 percent (%) (53-86 millimoles per mole [mmol/mol]) (both inclusive) as assessed by central laboratory at screening.
- Willingness to obtain a high weight loss (greater than [>] 25% of weight at baseline).
You may not qualify if…
- Treatment with any medication for the indication of diabetes or obesity other than stated in the inclusion criteria within 90 days before screening. However, short term insulin treatment for a maximum of 14 consecutive days and prior insulin treatment for gestational diabetes are allowed.
- Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination.
- Known hypoglycaemic unawareness as indicated by the investigator according to Clarke's Questionnaire.
Where it is running
- Opca bolnica Varazdin_Endocrinology — Varaždin, Croatia (enrolling)
- Poliklinika Solmed — Zagreb, Croatia (enrolling)
- Pacific Clinical Studies — Los Alamitos, California, United States (enrolling)
- First Valley Medical Group — Lancaster, California, United States (enrolling)
- Diablo Clinical Research, Inc. — Walnut Creek, California, United States (enrolling)
- Ark Clinical Research — Long Beach, California, United States (enrolling)
- Bioclinical Research Alliance — Miami, Florida, United States (enrolling)
- South Broward Research LLC — Miramar, Florida, United States (enrolling)
- Wetlin Research Associates, Inc. — San Diego, California, United States (enrolling)
- Torrance Clinical Research Institute, Inc. — Lomita, California, United States (enrolling)
- Elite Clinical Trials — Blackfoot, Idaho, United States (enrolling)
- Cedar-Crosse Research Center — Chicago, Illinois, United States (enrolling)
- Encore Medical Research LLC — Hollywood, Florida, United States (enrolling)
- Headlands Research — Springfield, Missouri, United States (enrolling)
- PharmQuest — Greensboro, North Carolina, United States (enrolling)
- Piedmont Healthcare Statesville — Statesville, North Carolina, United States (enrolling)
- Providence Center for Clinical Research — Dayton, Ohio, United States (enrolling)
- CNS Healthcare — Memphis, Tennessee, United States (enrolling)
- University of Texas Southwestern Medical Center — Dallas, Texas, United States (enrolling)
- JCCT- Juno NW Houston — Houston, Texas, United States (enrolling)
- Consano Clinical Research, LLC — Shavano Park, Texas, United States (enrolling)
- Encore Medical Research of Weston — Weston, Florida, United States (enrolling)
- Opca bolnica Karlovac — Karlovac, Croatia (enrolling)
- Poliklinika SLAVONIJA OSIJEK — Osijek, Croatia (enrolling)
- Akaicho Clinic_Internal medicine — Chiba-shi, Chiba, Japan (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.