Motor Eloquent Navigated Transcranial Magnetic Stimulation for Radiosurgery Planning
Recruiting now · Not applicable
Conditions studied: Metastases to Brain
In brief
With this project, the study group wants to investigate whether a postoperative navigated transcranial magnetic stimulation (nTMS) motor map can improve stereotactic radiosurgery (SRS) planning in patients who underwent resection for a brain metastasis near the primary motor cortex. Specifically, the map could allow for more precise location of motor eloquent tissue, thereby minimizing the radiation dose on these areas while preserving high radiation dose on target tissue (i.e. tumor cells).
Key facts
- Study ID
- NCT07415668
- Run by
- Insel Gruppe AG, University Hospital Bern
- People needed
- 30
- Starts
- 2026-05-08
- Expected to finish
- 2029-10-31
- Last updated by the study team
- 2026-08-04
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Informed consent
- Age ≥ 18 years
- Cerebral metastasis within or adjacent to the primary motor cortex (≤10 mm)
- Resection of tumor
- Eligible for and planned to undergo postresection radiosurgery at Inselspital Bern
You may not qualify if…
- Contraindication to TMS (e.g. Cochlear Implant, other metallic or electrical implants, excluding teeth and post craniotomy, Meniere's disease, pacemaker, deep brain stimulation electrodes, refractory convulsion, symptomatic tinnitus, depression diagnosed by a specialist, psychosis)
- Prior cerebral radiation therapy within the affected precentral gyrus/affecting the planned SRS plan
- Planned whole brain radiotherapy
- Second lesion within 2 cm ipsilateral in the primary motor cortex
- Infection or difficulties in wound healing within the last two weeks prior inclusion
- Pregnancy
Where it is running
- University Hostpital Bern, Department of Neurosurgery Bern — Bern, Switzerland (enrolling)
Full record on ClinicalTrials.gov
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