Cardiac Remodelling Following Endovascular Repair of the Aorta

Recruiting now

Conditions studied: Cardiac Failure, Aortic Disease

In brief

To assess the effects of endovascular aortic repair on cardiac morphology and function

Key facts

Study ID

NCT07415447

Run by

Lisbon Academic Medical Center - Centro Académico de Medicina de Lisboa

People needed

40

Starts

2025-09-01

Expected to finish

2027-09-01

Last updated by the study team

2026-02-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients over 18-year-old, with degenerative arch, descending thoracic or abdominal aortic aneurysms, penetrating aortic ulcers or intramural hematomas managed with total EVAR in elective setting.

You may not qualify if…

• Heart failure with an ejection fraction <35 vs 50% or New York Heart Association (NYHA) class III and IV.
• LV wall motion abnormality.
• Moderate to severe valve disease.
• History of (or expected within the study period) cardiac/aortic surgery.
• Coronary artery disease.
• Atrial fibrillation.
• Congenital heart disease.
• Connective tissue disorders.
• Chronic kidney disease (eGFR <30 mL/min/173 m2).
• Moderate to severe pulmonary disease as indicate either by post bronchodilator FEV1 (%predicted) <50% or Modified Medical Research Council Dyspnoea Scale (mMRC) 3-4.
• CMR contraindications (non-compatible pacemakers and metal implants, and claustrophobia).

Where it is running

• Unidade Local de Saúde Santa Maria — Lisbon, Portugal (enrolling)
• Unidade Local de Saúde de Santa Maria, E.P.E. — Lisbon, Portugal

Full record on ClinicalTrials.gov

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