Oxygen Reserve Index (ORi) in Identifying Desaturation

Starting soon · Not applicable

Conditions studied: Apneic Oxygenation, Endolarengeal Surgery, Oxygen Reserve Index

In brief

This randomized clinical trial investigates whether Oxygen Reserve Index (ORi) monitoring enables earlier detection of impending hypoxemia compared with conventional pulse oximetry during apneic intermittent ventilation in adult patients undergoing endolaryngeal surgery under general anesthesia. By providing continuous, noninvasive assessment of oxygen reserve in the hyperoxic range, ORi may offer an earlier warning of oxygen depletion before peripheral oxygen saturation declines. The study compares time to reventilation thresholds, arterial blood gas parameters, and perioperative respiratory outcomes between ORi-guided and standard SpO₂-guided monitoring strategies.

Key facts

Study ID

NCT07415161

Run by

Istanbul University

People needed

80

Starts

2026-01-27

Expected to finish

2026-03-25

Last updated by the study team

2026-02-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18 years or older
• Scheduled for elective endolaryngeal surgery
• Planned general anesthesia with apneic intermittent ventilation
• American Society of Anesthesiologists (ASA) physical status I-III
• Ability to provide written informed consent

You may not qualify if…

• Age under 18 years
• Preoperative chronic hypoxemia (baseline SpO₂ < 95%)
• Patients transferred from the intensive care unit
• ASA physical status IV or higher
• Refusal or inability to provide informed consent

Where it is running

• Istanbul University, Department of anesthesiology — Istanbul, Fatih, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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