Effectiveness of Targeted Cervical Length Screening Guided by a Preterm Birth Risk Scoring System in Reducing the Rate of Preterm Birth
Starting soon · Not applicable
Conditions studied: Preterm Birth
In brief
This cluster non-randomized controlled trial aims to evaluate the effectiveness and feasibility of a risk score-guided targeted cervical length screening strategy for the prevention of spontaneous preterm birth in routine community-based prenatal care. Pregnant women are first assessed using a simple preterm birth risk scoring system, and those identified as high risk undergo transvaginal cervical length screening followed by guideline-based preventive interventions when clinically indicated. The primary objective of the study is to compare this targeted screening strategy with usual prenatal care in reducing the incidence of spontaneous preterm birth occurring between 28 and 36 completed weeks of gestation. Secondary objectives include evaluating the cervical length screening rate, adherence to cervical length screening recommendations, and selected maternal and neonatal outcomes. Researchers will compare outcomes between women receiving risk score-guided targeted screening and those receiving routine prenatal care without use of the risk scoring system. All participants will be followed until delivery.
Key facts
- Study ID
- NCT07415070
- Run by
- Ningbo University
- People needed
- 1000
- Starts
- 2026-03-01
- Expected to finish
- 2027-12-01
- Last updated by the study team
- 2026-02-17
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- ·For community health service centers:
- Be located in the selected districts
- Provide prenatal care and be responsible for the registration and follow-up management of pregnant women
- Have the chief physician (or equivalent) agree to participate and to implement study-related risk assessment, referral, follow-up, and data collection procedures, and to receive standardized training
- For pregnant women:
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- Registered at participating community health service centers.
- Singleton pregnancy.
- No history of previous cervical cerclage.
- Able and willing to provide written informed consent and participate in the study.
You may not qualify if…
- for pregnant women:
- Multiple pregnancies.
- History of cervical cerclage.
- Medical indications requiring pregnancy termination.
- Any other condition that, in the opinion of the investigator, would make the participant unsuitable for the study.
Where it is running
- Ningbo University — Ningbo, Zhejiang, China
Full record on ClinicalTrials.gov
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