A Solid Tumor Study for Long Term Treatment of Cancer Patients Who Participated in Adagrasib Studies

Recruiting now · Phase 2

Conditions studied: Solid Tumors

In brief

This is an open-label, solid tumor, continuation, rollover trial which enrolls participants from ongoing BMS parent studies that evaluated adagrasib (MRTX849, BMS-986503) either as monotherapy or in combination with other cancer therapies in patients with non-small cell lung cancer (NSCLC), colorectal cancer (CRC) and other advanced solid tumors.

Key facts

Study ID

NCT07415031

Run by

Mirati Therapeutics Inc.

People needed

170

Starts

2026-05-06

Expected to finish

2028-02-16

Last updated by the study team

2026-07-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participant is eligible to receive continued study treatment as per the parent study, and/or investigator assessed clinical benefit.
• Individuals with assigned female sex at birth (AFSB) must have documented proof that they are not of childbearing potential. IOCBP participants who are sexually active must agree to follow the instructions for method(s) of contraception and included in the ICF.

You may not qualify if…

• Participant is not eligible for study treatment per the parent study eligibility criteria.
• Participants who have completed treatment with the study drugs, progressed on prior study treatment, or discontinued study treatment due to toxicity in the parent study are not eligible to receive study drug in this study.
• Participants not receiving clinical benefit from parent study drug as assessed by the investigator.
• Other protocol defined inclusion/exclusion criteria applies.

Where it is running

• Texas Oncology-Bedford — Bedford, Texas, United States (enrolling)
• Southern California Permanente Medical Group — Bellflower, California, United States (enrolling)
• Mayo Clinic in Rochester, Minnesota — Rochester, Minnesota, United States (enrolling)
• Texas Oncology - Baylor Charles A. Sammons Cancer Center — Dallas, Texas, United States (enrolling)
• The West Clinic, PLLC dba West Cancer Center — Germantown, Tennessee, United States (enrolling)
• Texas Oncology - DFW — Grapevine, Texas, United States (enrolling)
• Oncology Associates Of Oregon, Pc — Eugene, Oregon, United States (enrolling)
• Florida Cancer Specialists - North — St. Petersburg, Florida, United States (enrolling)
• Local Institution - 0092 — Boston, Massachusetts, United States
• Local Institution - 0038 — Changsha, Hunan, China
• Local Institution - 0112 — Wichita, Kansas, United States
• Local Institution - 0082 — Long Beach, California, United States
• Local Institution - 0036 — Omaha, Nebraska, United States
• Local Institution - 0072 — Vancouver, British Columbia, Canada
• Local Institution - 0073 — Saint Paul, Minnesota, United States
• Local Institution - 0033 — Ghent, Belgium
• Local Institution - 0093 — St Leonards, New South Wales, Australia
• Local Institution - 0013 — Bellingham, Washington, United States
• Local Institution - 0080 — Boston, Massachusetts, United States
• Local Institution - 0037 — Beijing, Beijing Municipality, China
• Local Institution - 0045 — Xiamen, Fujian, China
• Local Institution - 0042 — Zhengzhou, Henan, China
• Local Institution - 0003 — Newark, Delaware, United States
• Local Institution - 0046 — Nanjing, Jiangsu, China
• Local Institution - 0005 — Phoenix, Arizona, United States

Full record on ClinicalTrials.gov

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