Intravenous Lidocaine Plus Port-Site Ropivacaine for Recovery After Laparoscopic Surgery
Starting soon · Phase 3
Conditions studied: Intravenous Lidocaine, Laparoscopic Surgery, Post Operative Recovery, Local Anaesthetic Systemic Toxicity
In brief
This randomized controlled trial evaluates whether perioperative intravenous lidocaine infusion, combined with port-site ropivacaine infiltration, improves postoperative recovery after laparoscopic abdominal surgery. Participants will be assigned 1:1 to receive either intravenous lidocaine during surgery plus ropivacaine infiltration at surgical closure, or ropivacaine infiltration alone. The primary endpoint is postoperative quality of recovery measured by the QoR-15 questionnaire. Secondary endpoints include postoperative pain and opioid consumption, as well as plasma lidocaine and ropivacaine concentrations to assess systemic exposure and safety.
Key facts
- Study ID
- NCT07414706
- Run by
- Centre Hospitalier Universitaire, Amiens
- People needed
- 182
- Starts
- 2026-03-01
- Expected to finish
- 2028-09-01
- Last updated by the study team
- 2026-02-17
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Patient undergoing scheduled colorectal cancer surgery via laparoscopy.
- Patient aged 18 years or older.
- Informed consent obtained and signed.
- Affiliation to a social security system.
You may not qualify if…
- Allergy or contraindication to lidocaine or ropivacaine.
- Allergy or contraindication to paracetamol, nefopam ketamine, propofol, dexamethasone, sufentanil, Celebrex or parecoxib, morphine derivatives, and colorectal surgery by laparotomy
- Colorectal surgery with a non-cancerous indication.
- Chronic preoperative pain (defined as persistent pain for more than 3 months).
- Preoperative use of opioids or opioid derivatives.
- Patients with psychiatric disorders.
- Patients for whom self-assessment of pain using a self-reported scale cannot be performed (non-communicative, non-French speaking, etc.).
- Pregnant or breastfeeding women.
- Patients under guardianship, curatorship, or legal protection.
Where it is running
- CHU Amiens — Amiens, France
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.