Remotely Administered tDCS to Improve Cognitive Function in Veterans With mTBI and PTSD Principal Investigator
Starting soon · Phase 2 · Has a placebo group
Conditions studied: Cognition, Brain Injuries, Stress Disorders, Post-Traumatic
In brief
Traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) are common combat-related conditions that can result in impairments in cognition, including memory, attention and multi-tasking. There are few effective interventions to improve cognition in Veterans with cognitive impairment due to these conditions. Non-invasive brain stimulation techniques, like transcranial direct current stimulation (tDCS), can be used to stimulate activity in areas of the brain to optimize recovery and rehabilitation. In this study, the investigators are conducting a randomized controlled trial of tDCS to improve cognitive function in Veterans with cognitive impairment due to co-morbid TBI and PTSD. TDCS is remotely administered and paired with cognitive training.
Key facts
- Study ID
- NCT07414537
- Run by
- VA Office of Research and Development
- People needed
- 46
- Starts
- 2027-05-24
- Expected to finish
- 2030-11-30
- Last updated by the study team
- 2026-02-17
Who can join
Age: 20 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- History of chronic mTBI as measured by Ohio State University Traumatic Brain Injury Identification Method
- mTBI occurred > 5 years prior to study enrollment
- History of PTSD with symptoms within the last month as confirmed PTSD Checklist (past month) score greater than or equal to 33,
- Cognitive impairment as defined by telephone Montreal Cognitive Assessment < 19
- No history of reported or documented age-related or neurodegenerative condition
- Access to internet for 1 hour per day
- Willing and able to comply with all study related procedures and capable of independently reading and understanding study materials and providing informed consent.
You may not qualify if…
- Skin lesions at the stimulation site that may increase conductance
- Metallic objects in the face or head (e.g. braces, fillings, implants)
- Pregnancy/lactation or planning to become pregnant during study
- History of other significant neurological disorders including seizure disorder, central nervous system tumors, stroke, cerebral aneurysm
- History of primary psychotic disorder, bipolar I disorder, active substance use disorder (moderate or greater, measured by Drug Abuse Screening Test-10)
- Active suicidal intent or plan, measured by Columbia-Suicide Severity Rating Scale
- Other conditions or circumstances that, in the opinion of investigator team, have the potential to prevent completion and/or have a confounding effect on outcome assessments.
- Unable to tolerate 2mA transcranial direct current stimulation (tDCS)
Where it is running
- Corporal Michael J. Crescenz VA Medical Center, Philadelphia, PA — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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