6-month Clinical Investigation Assessing the Efficacy of an Antimicrobial Mouthrinse in Reducing Established Plaque and Improving Gum Health

Recruiting now · Phase 4

Conditions studied: Gingivitis, Dental Plaque Accumulation

In brief

The goal of this clinical trial is to evaluate the clinical efficacy of an antimicrobial mouthrinse, with a particular focus on its effect on established plaque and the improvement of gum health. Participants will: * Brush and rinse twice a day with the designated products for 6 months * Visit the clinic once every 3 months after baseline for reassessment.

Key facts

Study ID

NCT07414173

Run by

Colgate Palmolive

People needed

90

Starts

2026-01-28

Expected to finish

2026-11-01

Last updated by the study team

2026-02-17

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Male and female subjects aged 18-70 years, inclusive.
• Availability for the 6-month duration of the clinical research study.
• Good general health based on the opinion of the study investigator.
• Signed Informed Consent Form.
• Minimum of 20 natural teeth (excluding third molars).
• Initial gingivitis index of at least 1.5 as determined by the use of the Loe and Silness Gingival Index.
• Initial plaque index of at least 1.5 as determined by the use of the Quigley and Hein Plaque Index (Turesky Modification).

You may not qualify if…

• Be under orthodontic treatment.
• Presence of partial removable dentures.
• Tumor(s) of the soft or hard tissues of the oral cavity.
• Participants with current moderate or severe periodontitis (periodontitis screening index [PSI] >2 in more than 2 sextants or PSI >3), and/or purulent exudate, tooth mobility, and/or extensive loss of periodontal attachment or alveolar bone.
• Five or more carious lesions requiring immediate restorative treatment.
• Antibiotic use any time during the one-month period prior to entry into the study.
• Participation in any other clinical study or test panel within the one month prior to entry into the study.
• Dental prophylaxis during the past two weeks prior to baseline examinations.
• History of allergies to oral care/personal care consumer products or their ingredients.
• On any prescription medicines that might interfere with the study outcome based on the examiner/PI opinion.
• An existing medical condition that prohibits eating and/or drinking for periods up to 4 hours.
• History of alcohol and/or drug abuse.
• Self-reported pregnancy and/or lactating subjects.
• Subjects with other oral diseases (including gingival hyperplasia, diseases of the oral mucosa), or any condition that the dental examiner considers exclusionary from the study.
• Smokers or/and users of tobacco products.
• Enrolled in an undergraduate, postgraduate, or academic dentistry program

Where it is running

• SGS proderm GmbH — Schenefeld, Germany (enrolling)

Full record on ClinicalTrials.gov

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