French National Cohort of Patients With PRSS1 Mutations

Recruiting now

Conditions studied: Hereditary Pancreatitis, PRSS1 Gene Mutation

In brief

The diagnosis of hereditary pancreatitis (PH) is based on a genetic criterion - detection of a mutation in the PRSS1 gene or on a genealogical criterion - the presence of chronic pancreatitis in at least 2 first-degree relatives or at least 3 relatives in the second degree, in the absence of other identified predisposing factors (notably chronic alcohol consumption). It is now recommended to seek PH in cases of pancreatitis of unknown origin in a young patient or with a family history. In this study, patients carrying a PRSS1 mutation will be identified from the patient lists of the three French genetics laboratories (Brest University Hospital, Cochin-Paris University Hospital, Lille University Hospital) carrying out PRSS1 gene analysis. Patients will be included by the doctors currently treating them. The aim of the study is to assess the incidence of pancreatic adenocarcinoma in the cohort and describe the natural history of hereditary pancreatitis linked to a mutation in PRSS1.

Key facts

Study ID

NCT07413029

Run by

Assistance Publique - Hôpitaux de Paris

People needed

800

Starts

2024-11-10

Expected to finish

2044-12-31

Last updated by the study team

2026-02-17

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Being a carrier of a known genetic mutation in the PRSS1 gene coding for cationic trypsinogen
• Be followed in one of the participating centers

You may not qualify if…

• Opposition to data collection, expressed by the patient or one of their legal representatives

Where it is running

• REBOURS — Clichy-sous-Bois, France (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.