Healing of Apicomarginal Defects Using Autograft or Allograft With Collagen Membrane

Starting soon · Not applicable

Conditions studied: Apicomarginal Defects

In brief

Apicomarginal defects, which connect apical and marginal bone loss, are difficult to manage surgically due to their limited regenerative potential. Guided tissue regeneration using grafts and collagen membranes may improve outcomes, but the comparative effectiveness of autografts and allografts in these defects is not well established. This randomized clinical trial at PGIDS Rohtak will evaluate 36 patients undergoing endodontic microsurgery, assigning them to either autograft or allograft combined with a bioresorbable collagen membrane. Clinical and CBCT-based radiographic healing will be monitored over 12 months. The study aims to determine whether allografts can achieve bone regeneration comparable to autografts, offering a less invasive option for treating apicomarginal defects.

Key facts

Study ID

NCT07412067

Run by

Postgraduate Institute of Dental Sciences Rohtak

People needed

50

Starts

2026-04-01

Expected to finish

2026-12-01

Last updated by the study team

2026-02-17

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients aged ≥18 years. Presence of chronic suppurative apical periodontitis with an apicomarginal defect and deep periodontal pocket, suggesting endodontic-periodontal communication up to the apex.
• Negative response to pulp vitality tests.

You may not qualify if…

• Presence of root fractures or perforations. Patients with compromised systemic health (ASA II or above). Smokers.

Where it is running

• Post Graduate Institute of Dental Sciences, Rohtak — Rohtak, Haryana, India

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.