Enteral Versus Parenteral Nutrition During Recovery After Shock

Starting soon · Not applicable

Conditions studied: Shock, Critical Illness, Nutritional Support, Vasopressor Therapy

In brief

This study compares enteral nutrition and parenteral nutrition in critically ill adult patients recovering from shock while receiving decreasing doses of vasopressors in the intensive care unit. Eligible patients will be randomly assigned to receive either enteral or parenteral nutrition during the early recovery phase of shock. The study aims to determine whether enteral nutrition improves clinical outcomes, including ICU mortality and ICU-acquired infections, compared with parenteral nutrition.

Key facts

Study ID

NCT07411014

Run by

Samsung Medical Center

People needed

1150

Starts

2026-02-01

Expected to finish

2029-12-31

Last updated by the study team

2026-02-18

Who can join

Age: 19 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects must meet all screening criteria.
• Subjects must have central venous access suitable for the administration of parenteral nutrition (PN).
• Subjects must demonstrate a decreasing vasopressor requirement, defined as a current VIS of 12 or less at the time of enrollment.

You may not qualify if…

• Subjects with contraindications to enteral nutrition (EN) or parenteral nutrition (PN) at the time of enrollment will be excluded.
• Subjects requiring specific nutritional management, including but not limited to long-term home enteral nutrition, long-term parenteral nutrition, or a diagnosis of refeeding syndrome, will be excluded.
• Subjects who are pregnant or breastfeeding will be excluded.
• Subjects with severe comorbid conditions associated with an estimated life expectancy of less than three months will be excluded.
• Subjects with a documented do-not-resuscitate (DNR) order will be excluded.
• Subjects with active gastrointestinal bleeding will be excluded.
• Subjects who have undergone gastrointestinal surgery within one month prior to enrollment will be excluded.
• Subjects currently participating in another randomized controlled trial comparing enteral nutrition and parenteral nutrition will be excluded.

Where it is running

• Samsung Medical Center — Seoul, South Korea

Full record on ClinicalTrials.gov

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