Impact of Thyroid Hormones on Human Glucose and Energy Metabolism

Recruiting now · Not applicable

Conditions studied: Graves Disease, Thyroid Cancer

In brief

The goal of this clinical trial to clarify the impact of changes in thyroid hormone levels on glucose and lipid metabolism. Patients will be included in whom thyroid hormone levels are intentionally changed by treatment. In patients with Graves' disease, thyroid hormone levels will be lowered using medication, while in patients with thyroid cancer, thyroid hormone levels will be raised using medication. Oral glucose tolerance tests will be performed before treatment and at two time points after treatment begins to assess metabolic effects.

Key facts

Study ID

NCT07410637

Run by

University of Ulm

People needed

60

Starts

2026-02-04

Expected to finish

2031-06-01

Last updated by the study team

2026-02-13

Who can join

Age: any. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• patients with initial diagnosis of graves disease OR
• patients with initial diagnosis of thyroid carcinoma

You may not qualify if…

• contraindications for oral glucose tolerance test
• Diabetes mellitus
• Fasting glucose level ≥ 200 mg/dL
• Exogenous insulin administration with action at the time of the test
• Current disease with activation of stress hormones
• Post-aggressive metabolism
• Acute infectious disease

Where it is running

• Ulm University Hospital — Ulm, Baden-Wurttemberg, Germany (enrolling)

Full record on ClinicalTrials.gov

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