Comparison of Anesthetic Efficacy OF 2% Lidocaine Inferior Alveolar Nerve (IANB) Block Versus Primary Buccal Infilteration With 4% Articaine in Symptomatic Irreversible Pulpitis(SIP) IN Mandibular First Molars

Recruiting now · Not applicable

Conditions studied: Anesthetic Efficacy

In brief

This randomized controlled trial aims to compare the anesthetic efficacy of 2% lignocaine administered through an inferior alveolar nerve block (IANB) in one group of participants with 4% articaine delivered via primary buccal infiltration in other group in patients with symptomatic irreversible pulpitis in mandibular first molars.

Key facts

Study ID

NCT07409896

Run by

Armed Forces Institute of Dentistry, Pakistan

People needed

330

Starts

2026-03-20

Expected to finish

2026-08-20

Last updated by the study team

2026-07-30

Who can join

Age: 18 and older, up to 55. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Systemically healthy patients classified as ASA I, aged 18-55 years.
• Permanent mandibular first molar tooth requiring endodontic therapy.
• Diagnosed with symptomatic irreversible pulpitis without swelling or sinus.
• Normal periapical radiographic appearance (no evidence of periapical pathology).
• Moderate pain as assessed by the Heft-Parker VAS (>54 mm and <114 mm).
• Lingering pain or prolonged response to cold testing (lasting more than 10 seconds).
• Positive response to electric pulp testing.
• Outcome assessed must be pulpal anesthesia

You may not qualify if…

• • Pregnant or lactating mothers.
• Teeth with reversible pulpitis, previously treated, or with calcified canals.
• Teeth with severe periodontal disease or periapical radiolucency.
• Patients who have taken analgesics or anti-inflammatory drugs within 6 hours before the treatment visit.
• Patients on medications that could potentially interact with the anesthetic solution (e.g., antihypertensives, anticoagulants).
• History of allergy to 4% articaine, lidocaine, or epinephrine.
• Systemic diseases, immunocompromised states, or significant anxiety/mental health disorders.
• History of vasovagal syncope on local anesthetic administration

Where it is running

• Armed Forces Institute of Dentistry AFID CMH Rawalpindi — Rawalpindi, Punjab Province, Pakistan (enrolling)

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.