Optimizing Operational Parameters for Diagnostic Vitrectomy

Starting soon

Conditions studied: No Disease or Condition is Being Studied

In brief

Single-center ex-vivo study using blood samples from healthy donors processed through a 25-gauge vitrectomy system. The study compares four combinations of operational parameters (vacuum pressure and cut rate) to evaluate their impact on cellular recovery and morphological preservation. Pre- and post-procedure complete blood counts and cytology smears will be analyzed to identify the settings that minimize cell loss and mechanical damage, with the ultimate goal of optimizing diagnostic yield in vitreoretinal lymphoma (VRL) vitrectomy.

Key facts

Study ID

NCT07408466

Run by

IRCCS San Raffaele

People needed

100

Starts

2026-04-01

Expected to finish

2026-12-01

Last updated by the study team

2026-02-17

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Provision of written informed consent authorizing the anonymized research use of residual blood samples.
• Age 18-65 years at the time of donation.
• Eligibility for routine whole blood donation, according to the institutional and national standards of the Blood Transfusion Center.
• Good general health, as per standard donor screening procedures.

You may not qualify if…

• No additional exclusion criteria are defined beyond standard blood donation regulations. Exclusion from the study will therefore coincide with ineligibility for blood donation according to institutional protocols (e.g., due to infection, hematologic disease, recent surgery, or medication use that affects blood composition).

Full record on ClinicalTrials.gov

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