Effect of a Driving Pressure Adjustment Procedure for High-Frequency Jet Ventilation in Patients Undergoing Tumor Thermal Ablation in Interventional Radiology

Recruiting now · Not applicable

Conditions studied: Solid Tumor (Excluding CNS)

In brief

Tumor thermal ablation under Jet Ventilation is a procedure performed under general anesthesia that enables tumor ablation under radiological imaging guidance. This procedure, being less invasive than conventional surgery, allows for a faster recovery and hospital discharge. This procedure requires significant precision to ensure the most complete destruction of the tumor, while also preserving adjacent organs. During general anesthesia, respiratory movements complicate radiological localization and tumor destruction. The principle of High-Frequency Jet Ventilation (HFJV) involves using a device that ventilates a small volume of air and oxygen at a specific pressure, called driving pressure, at a high frequency. This ventilation mode reduces respiratory movements while ensuring continuous ventilation and oxygenation. This respiratory stability allows for the precision necessary to superimpose images for tumor localization and destruction. There are no guidelines regarding the driving pressure setting for HFJV for tumor thermal ablation. The method tested in this research is based on patient's height to optimize the driving pressure when using HFV. The main objective of this research is to evaluate the impact of driving pressure settings, on respiratory function, taking into account patient's height. On the day of the procedure, the driving pressure setting for the HFJV will be randomly assigned (1.4 bars, 1.9 bars, 2.4 bars, or customized according to the patient's height) (1 bar = 14 psi). The research will be conducted using medical data collected during routine patient care. Patient participation will last for the duration of their hospital stay, approximately two days.

Key facts

Study ID

NCT07408375

Run by

Nantes University Hospital

People needed

560

Starts

2026-03-13

Expected to finish

2028-03-13

Last updated by the study team

2026-03-27

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥ 18 years.
• Patient undergoing thermal ablation of a solid tumor under HFJV.
• Patient who has given their consent.
• Patient covered by a social security scheme.

You may not qualify if…

• Patient under guardianship or curatorship.
• Patient who does not understand French.
• Pregnant and breastfeeding woman
• Patient who has had a pneumonectomy
• Patient requiring an endotracheal tube smaller than 6.5

Where it is running

• CHU de Nantes — Nantes, France (enrolling)
• Institut Gustave Roussy — Villejuif, France (enrolling)
• CHU de Lyon — Lyon, France
• CHU de Poitiers — Poitiers, France
• ICO Unicancer — Saint-Herblain, France
• CHU de Nîmes — Nîmes, France
• Centre Léon Bérard — Lyon, France

Full record on ClinicalTrials.gov

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