Sodium Bicarbonate as an Alternative to Potassium Citrate for Kidney Stones

Starting soon · Phase 1/Phase 2

Conditions studied: Kidney Stones, Urolithiasis, Hypocitraturia, Nephrolithiasis

In brief

Kidney stones affect 1 in every 11 people in the US each year. In patients with kidney stones who are prescribed medications for stone management, only 30.2% are adherent to a medication regime and even fewer, only 13.4 % are adherent with citrate medications. Prescription potassium citrate can be expensive for many patients, leading to non-compliance. Sodium bicarbonate is a potential medication alternative that is cheaper and can potentially alkalinize the urine and/or decrease the risk of future kidney stones. However, efficacy of alternatives to potassium potassium citrate are not well studied. This study seeks to evaluate sodium bicarbonate and assess its ability to alkalinize urine in a cohort of patients with kidney stones and compare this to prescription potassium citrate.

Key facts

Study ID

NCT07408076

Run by

University of California, Los Angeles

People needed

30

Starts

2026-02-01

Expected to finish

2028-02-01

Last updated by the study team

2026-02-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult >18 years of age
• History of nephrolithiasis
• One 24h urine collections within one year of enrollment with hypocitraturia.
• Patients currently utilizing or considering use of Kcit for stone prevention

You may not qualify if…

• Individuals with known metabolic disorders
• Individuals with other known causes of nephrolithiasis
• Anyone who, in the opinion of the PI, is unfit or unsuitable to participate in the study

Where it is running

• University of California, Los Angeles — Los Angeles, California, United States
• University of California, Davis — Sacramento, California, United States
• University of California, San Diego — San Diego, California, United States
• Brigham & Women's — Boston, Massachusetts, United States
• CHUM — Montreal, Canada
• Landspitali- National University Hospital of Iceland — Reykjavik, Iceland

Full record on ClinicalTrials.gov

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