Comparative Efficacy Of Intraductal Antibiotic During ERCP In Acute Cholangitis

Recruiting now · Phase 2

Conditions studied: Acute Cholangitis, Biliary Tract Infection, Biliary Obstruction, Choledocholithiasis, Malignant Biliary Stricture

In brief

Does intraductal administration of antibiotics during endoscopic retrograde cholangiopancreatography (ERCP), in addition to standard systemic antibiotic therapy, improve clinical outcomes in patients with acute cholangitis compared with standard systemic antibiotic therapy alone?

Key facts

Study ID

NCT07407491

Run by

National University of Malaysia

People needed

172

Starts

2024-07-09

Expected to finish

2026-07-08

Last updated by the study team

2026-02-12

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• The patients diagnosed with mild and moderate acute cholangitis based on TG 18
• Planned for ERCP within 48 hours
• 18 years old and above

You may not qualify if…

• Severe acute cholangitis
• History of antibiotic hypersensitivity
• Receiving cancer chemotherapy, steroids, or immunosuppressive agents
• Concomitant infections
• Recent biliary interventions such as percutaneous transhepatic biliary drainage (PTBD) within last 3 months
• Known or suspected perforated tympanic membrane, myasthenia gravis

Where it is running

• Hospital Canselor Tuanku Muhriz UKM — Cheras, Kuala Lumpur, Malaysia (enrolling)

Full record on ClinicalTrials.gov

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