EEG-Guided Binaural Beat Audio to Reduce Performance-Related Stress and Improve Cognition

Starting soon · Not applicable

Conditions studied: Cognitive Abilities, Performance, Stress, Cognitive Performance

In brief

Performance-related stress can impair sustained attention, inhibitory control, and memory. This randomized, double-blinded, sham-controlled parallel-arm trial evaluates whether a 30-minute EEG-guided binaural beat audio intervention reduces subjective stress/performance anxiety and improves cognition, and whether it changes task-related brain reactivity measured by fMRI. The intervention uses real-time single-electrode EEG recorded over the left prefrontal cortex to dynamically adjust binaural beat frequencies to guide the brain toward a target state; the sham condition uses non-binaural music delivered through identical headphones. Adult music majors preparing for an upcoming concert will complete pre- and post-intervention fMRI sessions during cognitive/music tasks (Stop Signal Reaction Task, Music Reading Task, Music Memory Retrieval Task) and complete visual analog scales (VAS) assessing performance anxiety, stress, and related subjective states. The primary outcomes include fMRI task-related activity in stress-regulation regions (dlPFC, amygdala, hippocampus), behavioral inhibition indices from the stop-signal task, music memory retrieval accuracy, and VAS-reported stress/performance anxiety.

Key facts

Study ID: NCT07407426
Run by: Texas Tech University Health Sciences Center
People needed: 32
Starts: 2026-04-07
Expected to finish: 2026-08-30
Last updated by the study team: 2026-04-13

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

Adults (18+ years) enrolled as undergraduate music majors at Texas Tech University
Currently preparing for an upcoming concert performance within the next 3 months
Able to read standard musical notation

You may not qualify if…

Subjects with contraindications to undergo MRI after being screened by the TTNI safety screening sheet - specifically, Subjects with implanted devices that are not compatible with MRI including, but not limited to cardiac pacemakers, cardiac defibrillators, aneurysm clips, carotid artery vascular clamps, implanted nerve stimulators (neuron-stimulators also called TENS or wires), bone growth or bone fusion stimulators, cochlear implants, vagus nerve stimulators, filters for blood clots (Umbrella, Greenfield, bird's nest), embolization coils (e.g. Gianturco) in the brain, ocular implants, vascular stents, medication pumps, medication patches delivering medications, implanted limbs, ventricular shunts, metal joints, rods, plates, pins, screws, nails, or clips, penile implants, or contraceptives devices including IUDs, cervical pessaries and diaphragms Subjects who have undergone cataract surgery Subjects who have shrapnel or metal in the head, eyes or skin Subjects with a history of working with metal fragments ( or have had metal removed from eyes Subjects with gunshot wounds or BB gun injury Subjects with permanent metal body piercings or jewelry that cannot be removed Subjects who use hearing aids or have braces / permanent retainers that cannot be removed temporarily for the MRI scans Subjects with large tattoos in the head and neck area Subjects with claustrophobia Subjects who are currently pregnant or suspected to be pregnant
Physical, medical, neurological or psychiatric impairments (including substance abuse)
Current use of medications that could affect cognitive performance (including beta-blockers, stimulants, anxiolytics, antidepressants, or antipsychotics)
History of head injury resulting in loss of consciousness/history of brain surgery
History of diagnosed hearing impairment or use of hearing aids
Current or past diagnosis of epilepsy or seizure disorders
Unwillingness or inability to refrain from alcohol consumption 48 hours prior to the study visit
Unwillingness or inability to refrain from caffeine consumption 12 hours prior to the study visit
Current/past history of substance abuse
Pregnancy or possibility of pregnancy
Unwillingness or inability to follow written, on-screen, and verbal instructions given by the study team

Where it is running

Texas Tech University — Lubbock, Texas, United States

Full record on ClinicalTrials.gov

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