Combined Chemotherapy And Ablative Radiotherapy (SBRT) As First-Line Treatment In Locally Advanced Inoperable Pancreatic Cancer (SBRT-PANC)

Recruiting now · Not applicable

Conditions studied: Locally Advanced Pancreatic Cancer

In brief

This prospective interventional clinical study evaluates the efficacy and safety of combining systemic chemotherapy followed by ablative stereotactic body radiotherapy (SBRT) as first-line treatment in adult patients with locally advanced, inoperable pancreatic cancer. The study aims to determine the response rate after SBRT delivered following initial chemotherapy, as well as time to disease progression and treatment-related toxicity. Patients receive standard first-line chemotherapy and, in the absence of disease progression, undergo ablative SBRT to the primary tumor, followed by continuation of systemic therapy according to clinical practice. The study is conducted in Slovenia, with patient enrollment expanded to additional participating clinical centers following an approved amendment.

Key facts

Study ID

NCT07407231

Run by

Institute of Oncology Ljubljana

People needed

18

Starts

2021-09-01

Expected to finish

2026-12-31

Last updated by the study team

2026-02-17

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adults aged 18 years and older
• Locally advanced, inoperable pancreatic cancer
• Treated with first-line systemic chemotherapy followed by stereotactic body radiotherapy (SBRT) at participating centers
• Ability to provide written informed consent

You may not qualify if…

• Metastatic pancreatic cancer
• Prior systemic therapy for locally advanced pancreatic cancer (one or more previous lines of systemic treatment)
• Disease progression after initial chemotherapy prior to SBRT
• Any condition that, in the investigator's opinion, would interfere with study participation or evaluation

Where it is running

• Institute of Oncology Ljubljana — Ljubljana, Slovenia (enrolling)

Full record on ClinicalTrials.gov

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