Oral Antioxidant Therapy Targeted to the Mitochondria for Improving Brain Artery Health in Postmenopausal Women
Starting soon · Not applicable · Has a placebo group
Conditions studied: Aging, Postmenopause
In brief
The goal of this clinical trial is to learn if 3 months of taking the dietary supplement MitoQ \[a mitochondria-targeted antioxidant that targets to reduce mitochondrial reactive oxygen species (mitoROS)\] works to treat age- and menopause-related reductions in brain artery (cerebrovascular) function in postmenopausal women 60 years of age or older free of clinical disease. The main questions it aims to answer are: Does MitoQ improve cerebrovascular function in postmenopausal women? If so, does MitoQ improve cerebrovascular function by lowering mitoROS in these arteries? Researchers will compare MitoQ to a placebo (a look-alike substance that contains no drug) to see if MitoQ can improve cerebrovascular function by lowering mitoROS in arteries involved in brain health and function. Participants will: Take MitoQ (20 mg/day) or a placebo every day for 3 months Visit the research laboratory at baseline and then after 3 months for cerebrovascular testing; there is also a check-in visit at 6 weeks, which is the halfway point Keep track of symptoms and events during their treatment period to report to the study team
Key facts
- Study ID
- NCT07406243
- Run by
- Colorado State University
- People needed
- 86
- Starts
- 2026-04-01
- Expected to finish
- 2030-07-01
- Last updated by the study team
- 2026-02-12
Who can join
Age: 60 and older. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Age 60 years or older;
- Postmenopausal women defined as at least 1 year without menses as self-reported;
- Estrogen-deficient; no hormone therapies (e.g., estrogen, progesterone, testosterone, DHEA, oral contraceptives, etc.) within the previous 6 months;
- Ability to provide informed consent;
- Willing to accept random assignment to condition;
- Body mass index (BMI) ≤35 kg/m2;
- Mini-mental state examination score ≥21;
- Weight stable in the prior 3 months;
- Abstinence from antioxidant or CoQ10 therapy for 3 months; and
- Absence of clinical disease as determined by the physician of record following a medical history and blood chemistries
You may not qualify if…
- History of uncontrolled hypertension;
- Currently meeting aerobic exercise guidelines of ≥75 mins/week of vigorous or ≥150 mins/week of moderate intensity exercise as assessed by Modified Activity Questionnaire;
- Current smoker;
- Alcohol dependence or abuse;
- Other chronic medical conditions; and
- Subject report of blood donation within 8 weeks prior to enrolling.
Where it is running
- Translational Physiology Laboratory within the Food Science Clinical Research Laboratory — Fort Collins, Colorado, United States
Full record on ClinicalTrials.gov
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