the Efficacy of Hyperbaric Oxygen on Acute Ankle Sprain

Starting soon · Not applicable

Conditions studied: Ankle Sprain

In brief

Investigators recruited 208 patients with acute ankle sprain who were from the Rehabilitation Department of the Second Affiliated Hospital of Zhejiang University, School of Medicine from January 2026 to November 2028. Perform the improvement in AOFAS scores and Baird-Jackson ankle scores study and Rehabilitation assessments followed up after 3 years.

Key facts

Study ID

NCT07405281

Run by

Second Affiliated Hospital, Zhejiang University, School of Medicine

People needed

208

Starts

2026-03-01

Expected to finish

2029-03-01

Last updated by the study team

2026-02-12

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Unilateral ankle sprain;
• Swelling, bruising, and pain at the site of the sprain;
• Injury occurring within 72 hours;
• MRI examination clearly shows ligament damage.

You may not qualify if…

• X-ray shows ankle fracture;
• Ankle has skin lesions or skin diseases;
• History of lower limb and pelvic surgery;
• Obvious neurological or psychiatric disorders that may interfere with assessment;
• Severe ligament injuries or joint instability requiring surgical treatment;
• Previous ankle injuries, persistent pain or functional limitations;
• Pneumothorax, severe emphysema, active bleeding, or other diseases with contraindications for hyperbaric oxygen therapy.

Full record on ClinicalTrials.gov

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