Effect of Vagus Nerve Stimulation on Pain Intensity, Nerve Conduction Studies and Functional Outcomes in Diabetic Peripheral Neuropathy Patients
Recruiting now · Not applicable · Has a placebo group
Conditions studied: Transcutaneous Vagal Nerve Stimulation (tVNS), Diabetic Polyneuropathy
In brief
To evaluate the efficacy of vagus nerve stimulation in reducing neuropathic pain, symptom severity, electrophysiological studies and functional outcomes in patients with diabetic peripheral neuropathy.
Key facts
- Study ID
- NCT07405021
- Run by
- Cairo University
- People needed
- 40
- Starts
- 2026-01-01
- Expected to finish
- 2026-04-01
- Last updated by the study team
- 2026-02-12
Who can join
Age: 45 and older, up to 60. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Thirty patients diagnosed with diabetic neuropathy of both genders.
- Age range between 45 and 60 years.
- Presence of numbness and/or pain in the feet with no other identifiable cause.
- Pain characterized as stabbing, electric shock-like, or burning in nature.
- Presence of glove-stocking sensory changes and abnormal sensations in the distal lower limbs.
- Ability to ambulate independently without assistance.
- Patients under full medical control.
- Hemoglobin A1c levels ranging from 6.5% to 7%.
- History of diabetes mellitus for more than 5 years.
You may not qualify if…
- Implantation of cardiac pacemakers or other electrical stimulation devices.
- Presence of sinus bradycardia, sick sinus syndrome, or other cardiac arrhythmias.
- Lumbar radiculopathy.
- Psychiatric or mental disorders or history of seizures.
- Visual or auditory impairments or tremors affecting balance.
- Presence of other neuromuscular disorders.
- Foot deformities or active foot ulcers.
- History of lower limb surgical operations.
Where it is running
- outpatient clinic, faculty of physical therapy, Horus university — Damietta, Egypt (enrolling)
Full record on ClinicalTrials.gov
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