Non-invasive Vagus Nerve Stimulation to Reduce Inflammation and Brain Injury Blood Biomarkers Following an Acute Ischemic Stroke

Recruiting now · Not applicable · Has a placebo group

Conditions studied: Large Vessel Occlusion, Acute Ischemic Stroke

In brief

This is a randomized open-label, with blinded outcome pilot study to evaluate the effect on inflammatory and brain injury laboratory values and explore clinical outcomes in patients who present with ischemic strokes due to large vessel occlusions and are treated with either current accepted management, or accepted management in addition to transcutaneous auricular vagal nerve stimulation.

Key facts

Study ID

NCT07404852

Run by

Washington University School of Medicine

People needed

65

Starts

2026-02-23

Expected to finish

2028-02-29

Last updated by the study team

2026-04-13

Who can join

Age: 18 and older, up to 99. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Adult patients who present with acute ischemic strokes due to large vessel occlusions

You may not qualify if…

• <18 years old
• patients with presumed chronic large vessel occlusions
• NIHSS<6
• pre-morbid modified Rankin score (mRS) >2
• unable to initiate treatment under 24 hours from symptom discovery
• Chronic or acute infection, Recent surgery, active immune disease
• life expectancy <3 months
• patients' undergoing active cancer or immunosuppressive/modulating therapy
• patients with sustained bradycardia on arrival with a heart rate <50 beats per minute.

Where it is running

• Barnes-Jewish Hospital — St Louis, Missouri, United States (enrolling)

Full record on ClinicalTrials.gov

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