OPEN-IPF: Observational Prediction modEl for cliNical Outcomes in Idiopathic Pulmonary Fibrosis

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Conditions studied: Idiopathic Pulmonary Fibrosis

In brief

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with marked inter-individual heterogeneity in trajectories and outcomes. Despite antifibrotic therapies, reliable risk stratification in routine practice remains suboptimal. OPEN-IPF is a multicentre retrospective observational cohort study designed to build a harmonised real-world dataset across Italian IPF referral centres to enable the development and external validation of machine-learning (ML) models predicting clinically relevant outcomes.

Key facts

Study ID

NCT07404423

Run by

University of Modena and Reggio Emilia

People needed

1000

Starts

2026-06-01

Expected to finish

2027-06-01

Last updated by the study team

2026-02-11

Who can join

Age: 18 and older, up to 90. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age ≥18 years
• Diagnosis of idiopathic pulmonary fibrosis established according to international guidelines and local multidisciplinary team (MDT) assessment
• Availability of baseline clinical and functional data
• Availability of follow-up data for at least 12 months, or until a clinically relevant event (e.g., death, lung transplantation)

You may not qualify if…

• Interstitial lung disease other than IPF
• Lung transplantation performed before the baseline (index) date
• Absence of any follow-up information after baseline

Full record on ClinicalTrials.gov

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