Oxygen Reserve Index-Guided Oxygen Titration During Surgery in the Beach Chair Position

Starting soon · Not applicable

Conditions studied: Hyperoxemia, Intraoperative Oxygen Therapy, Beach Chair Position, Cerebral Oxygenation

In brief

This study aims to evaluate whether guidance by the Oxygen Reserve Index (ORi) improves inspiratory oxygen fraction (FiO₂) titration compared with conventional pulse oximetry (SpO₂)-guided oxygen administration in adult patients undergoing surgery in the beach chair position. Oxygen therapy is routinely used during general anesthesia to prevent hypoxemia; however, excessive oxygen administration may result in hyperoxia, which has been associated with adverse cardiovascular and pulmonary effects. Standard pulse oximetry may not adequately detect hyperoxia when oxygen saturation values are high. In this prospective comparative study, patients will receive oxygen titration guided either by SpO₂ alone or by combined ORi and SpO₂ monitoring. The primary outcome is the incidence of intraoperative hyperoxemia, assessed by arterial blood gas analysis. Secondary outcomes include intraoperative oxygenation parameters and hemodynamic variables.

Key facts

Study ID

NCT07404267

Run by

Fatih Sultan Mehmet Training and Research Hospital

People needed

80

Starts

2026-02-15

Expected to finish

2026-07-31

Last updated by the study team

2026-02-11

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adult patients aged 18 to 65 years
• American Society of Anesthesiologists (ASA) physical status I-III
• Scheduled for elective orthopedic surgery in the beach chair position
• Body mass index (BMI) <35 kg/m²
• Ability to provide written informed consent

You may not qualify if…

• Age <18 or ≥65 years
• Finger deformities preventing the use of Oxygen Reserve Index (ORi) monitoring
• Severe anemia (hemoglobin <8 g/dL)
• Pregnancy
• Refusal or inability to provide informed consent
• History of stroke or significant vascular pathology
• Severe cardiac or respiratory disease

Where it is running

• Istanbul Provincial Health Directorate Fatih Sultan Mehmet Training and Research Hospital — Istanbul, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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