Effects of Ankle Block on Postoperative Analgesia in Diabetic and Non-Diabetic Patients

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Conditions studied: Diabetes Mellitus, Diabetic Neuropathy, Postoperative Pain Management

In brief

This prospective observational study aims to evaluate the effects of ultrasound-guided ankle block on sensory and motor block characteristics and postoperative analgesic outcomes in patients undergoing lower extremity surgery. The study will compare diabetic and non-diabetic patients and will also assess the impact of glycemic control on block onset time and postoperative analgesic consumption. Ankle block is commonly used in patients undergoing foot and ankle surgery, particularly in those with diabetes, peripheral neuropathy, or vascular disease, when general or neuraxial anesthesia may not be suitable. Previous studies suggest that diabetic neuropathy and impaired glycemic control may influence the onset and duration of peripheral nerve blocks. Adult patients scheduled for lower extremity surgery under ankle block will be included. All procedures will be performed as part of routine clinical care, and no additional interventions will be applied for research purposes. Sensory and motor block onset times, postoperative pain scores, opioid consumption within the first 24 hours, and patient and surgeon satisfaction will be recorded. The results of this study are expected to provide clinically relevant information regarding the effects of diabetes and glycemic control on ankle block characteristics and postoperative analgesia.

Key facts

Study ID

NCT07404124

Run by

Fatih Sultan Mehmet Training and Research Hospital

People needed

46

Starts

2026-03-01

Expected to finish

2026-11-01

Last updated by the study team

2026-02-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adults aged 18 years and older.
• Patients scheduled for lower extremity surgery under ultrasound-guided ankle block as part of routine clinical care.
• Patients able to provide written informed consent.
• Availability of complete perioperative data including blood glucose levels, -HbA1c values, pain scores, and postoperative analgesic consumption.

You may not qualify if…

• Refusal or inability to provide informed consent.
• Failure of ankle block requiring conversion to another anesthesia technique.
• Known coagulation disorders contraindicating peripheral nerve block.
• Active infection at the site of block application.
• Chronic opioid or analgesic use, chronic alcohol use, or substance abuse.
• History of diabetic ketoacidosis or hyperosmolar hyperglycemic state.
• Severe renal or hepatic insufficiency.
• Known allergy to local anesthetics such as lidocaine or bupivacaine.
• Inability to perform perioperative blood glucose monitoring.
• Cognitive impairment or psychiatric conditions interfering with study participation or data collection.

Where it is running

• Istanbul Provincial Health Directorate Fatih Sultan Mehmet Training and Research Hospital — Istanbul, Turkey (Türkiye)

Full record on ClinicalTrials.gov

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